Men's Health · TRT

What studies have been done on TRT?

What the research says about testosterone therapy

Research into testosterone replacement therapy (TRT) has grown significantly in recent years, with large-scale studies helping to clarify both its benefits and its risks. Here's a look at one of the most notable, and what it means for you.

44,000+ menin a major 2019 review

Sexual-health gainslibido & satisfaction

Reduced EDsymptom improvement

Supervisionstill essential

A major 2019 review

44,000+

A notable 2019 review involving more than 44,000 men with low testosterone found that TRT can play a meaningful role in regulating the male sexual response cycle.

The findings showed improvements across several key areas — and TRT was associated with a reduction in symptoms of erectile dysfunction, making it a potentially valuable option for men experiencing hormone-related sexual health issues.

What the review found

In men with low testosterone, the review reported improvements in:

Improved libido

Better erection quality

Greater sexual satisfaction

Reduced symptoms of ED

Important context

While results are generally positive for appropriately selected patients, researchers continue to emphasise the importance of medical supervision and individual assessment before starting therapy. Ongoing studies aim to better understand the long-term effects of TRT and to optimise treatment protocols.

The source

Published in JAMA Internal Medicine (2019) Large-scale review of testosterone therapy and the male sexual response.
Read the full study on JAMA Network ›

Your Men's Health GP

Dr Liam Jordan

GP · Men's Health & TRT

Dr Jordan leads our testosterone replacement therapy service, combining the latest evidence with careful individual assessment and ongoing monitoring to deliver safe, effective care.

TRT FAQs

Does TRT improve sexual health?

A large 2019 review found that, in men with low testosterone, TRT was associated with improvements in libido, erection quality and overall sexual satisfaction, along with a reduction in symptoms of erectile dysfunction. Individual results vary.

Is TRT safe?

Research is generally positive for appropriately selected patients, but the studies stress the importance of medical supervision and individual assessment. We provide TRT only where clinically appropriate, after assessment and blood tests, with ongoing monitoring.

Is more research being done?

Yes. Ongoing studies aim to better understand the long-term effects of TRT and to optimise treatment protocols, so clinical guidance continues to evolve.

Considering TRT?

Book a consultation for an evidence-based, individual assessment — and find out whether TRT is right for you.

Book a consultation Contact the team

This page summarises published research for general information only and is not personal medical advice. Study findings describe outcomes across groups of appropriately selected patients; individual results vary. Testosterone replacement therapy is a prescription-only treatment provided only where clinically appropriate, following assessment and blood tests, with ongoing monitoring.